Mitochondrial H2O2 decarboxylates PYR to acetate

Stable Identifier
R-HSA-9861745
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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Mitochondrial H2O2 decarboxylates PYR to acetate
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In the presence of hydrogen peroxide (H2O2), pyruvate (PYR) is converted to acetate non-enzymatically. H2O2 is the end product of reactive oxygen species (ROS) degradation, usually from the reduction of superoxide (O2-). Under typical cell culture conditions, when there is active PDH and aKGDH, ROS contribute to around 5-15% of the acetate production. Thus, pyruvate may naturally function as a ROS scavenger (Liu et al., 2018).
Literature References
PubMed ID Title Journal Year
30245009 Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

Kirsch, DG, Garcia, BA, Wellen, KE, Lund, PJ, Locasale, JW, Lopes, M, Cooper, DE, Liu, X, Zhao, S, Warmoes, MO, Liu, J, Cluntun, AA, Reid, MA

Cell 2018
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Authored
Stephan, R  (2024-02-21)
Reviewed
Hill, DP  (2024-02-23)
Created
Stephan, R  (2024-02-21)
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