Reactome | MLPH/MYRIP bind GGC-RAB27A and MYO5A

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MLPH/MYRIP bind GGC-RAB27A and MYO5A Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
category	binding
compartment	[Compartment:5668575] melanosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9856459] Rothfels, Karen, 2023-12-18
dbId	9856465
displayName	MLPH/MYRIP bind GGC-RAB27A and MYO5A
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8877281] GGC-RAB27A [melanosome membrane] [DefinedSet:R-HSA-9856440] MLPH,MYRIP [cytosol] [Complex:R-HSA-9605106] p-S1652-MYO5A dimer [cytosol] [EntityWithAccessionedSequence:R-HSA-9856433] SYTL2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9732023] Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport [LiteratureReference:9732019] MYO5A Gene Is a Target of MITF in Melanocytes [LiteratureReference:9856416] Rab GTPases and myosin motors in organelle motility [LiteratureReference:9856397] Melanosomes on the move: a model to understand organelle dynamics [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9856394] Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions [LiteratureReference:9856398] MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes [LiteratureReference:9856429] Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport [LiteratureReference:9856425] Rab27a: A key to melanosome transport in human melanocytes [LiteratureReference:9856410] Myosin-Va contributes to manifestation of malignant-related properties in melanoma cells [LiteratureReference:9856404] Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport [LiteratureReference:9856421] Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes [LiteratureReference:9856375] A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion [LiteratureReference:9856389] Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MLPH/MYRIP bind GGC-RAB27A and MYO5A
orthologousEvent	[Reaction:R-GGA-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Gallus gallus [Reaction:R-SSC-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Sus scrofa [Reaction:R-BTA-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Bos taurus [Reaction:R-CFA-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Canis familiaris [Reaction:R-RNO-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Rattus norvegicus [Reaction:R-MMU-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Mus musculus
output	[Complex:R-HSA-9856444] GGC-RAB27A:MLPH,MYRIP:SYTL2:p-S1652-MYO5A dimer [melanosome membrane]
precedingEvent	[Reaction:R-HSA-1449597] p-AKT2 phosphorylates Myosin 5A - Homo sapiens [BlackBoxEvent:R-HSA-9856460] MITF-M-dependent RAB27A expression - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9856465
summation	[Summation:9856453] MITF-M-dependent transcriptional targets RAB27A and MYO5A pl...

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[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation

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