Reactome | MLPH/MYRIP bind GGC-RAB27A and MYO5A

MLPH/MYRIP bind GGC-RAB27A and MYO5A

Stable Identifier

R-HSA-9856465

Type

Reaction [binding]

Species

Homo sapiens

Compartment

melanosome membrane, cytosol

ReviewStatus

5/5

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MITF-M-dependent transcriptional targets RAB27A and MYO5A play a role in melanosome organization and maturation by regulating melanosome distribution (Chiaverini et al, 2008; Alves et al, 2017; reviewed in Hume and Seabra, 2011; Seabra and Coudrier, 2004; Cheli et al, 2010; Goding and Arnheiter, 2019). Melanosome-bound RAB27A and the actin-binding protein MYO5A form a complex mediated by the RAB effector protein MLPH, also known as melanophilin, or the RAB effector MYRIP (Nagashima et al, 2002; El-Amraoui et al, 2002). This heteromeric complex directs localization of melanosomes to the tips of dendrites prior to loading of melanosomes into adjacent keratinocytes (Bahadoran et al, 2001; Nagashima et al, 2002; El-Amraoui et al, 2002; Fukuda et al, 2002; Alves et al, 2013; Evans et al, 2014; Alves et al, 2017). Docking at the plasma membrane may be facilitated by SYTL2, another RAB27A-binding protein (Kuroda and Fukuda, 2004; Menasche et al, 2008; Yu et al, 2007. Note that the existence of a complex containing each of SYTL2, RAB27A, MYO5A and either MLPH or MYRIP has not been explicitly demonstrated.

Literature References

PubMed ID	Title	Journal	Year
11266474	Rab27a: A key to melanosome transport in human melanocytes Casaroli-Marano, R, Bille, K, Ballotti, R, Mantoux, F, Bahadoran, P, Ortonne, JP, Buscà, R, Aberdam, E, Yalman, N, de Saint-Basile, G	J Cell Biol	2001
12062444	Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions Igarashi, M, Yi, Z, Takeuchi, T, Nagashima, K, Torii, S, Izumi, T, Okamoto, K	FEBS Lett	2002
11856727	Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport Fukuda, M, Kuroda, TS, Mikoshiba, K	J Biol Chem	2002
21936787	Melanosomes on the move: a model to understand organelle dynamics Seabra, MC, Hume, AN	Biochem Soc Trans	2011
11964381	MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes Petit, C, Blanchard, S, Henry, JP, Küssel-Andermann, P, El-Amraoui, A, Wolfrum, U, Schonn, JS, Desnos, C, Darchen, F	EMBO Rep	2002
19995375	Fifteen-year quest for microphthalmia-associated transcription factor target genes Bertolotto, C, Cheli, Y, Ohanna, M, Ballotti, R	Pigment Cell Melanoma Res	2010
31123060	MITF-the first 25 years Arnheiter, H, Goding, CR	Genes Dev	2019
15117313	Rab GTPases and myosin motors in organelle motility Seabra, MC, Coudrier, E	Traffic	2004
17182843	Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain Yu, M, Takeuchi, T, Gomi, H, Nagashima, K, Kasai, K, Yokota-Hashimoto, H, Torii, S, Izumi, T, Okamoto, K	Mol Biol Cell	2007
15543135	Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes Fukuda, M, Kuroda, TS	Nat Cell Biol	2004
23652798	Myosin-Va contributes to manifestation of malignant-related properties in melanoma cells Trindade, DM, Ramão, A, Alves, CP, Yokoyama, S, Pontes, CLS, Sousa, JF, Moraes, MH, Fisher, DE, Espreafico, EM	J Invest Dermatol	2013
27939378	MYO5A Gene Is a Target of MITF in Melanocytes Alves, CP, Yokoyama, S, Sousa, JF, Goedert, L, Fisher, DE, Pontes, CLS, Espreafico, EM	J Invest Dermatol	2017
18281284	Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport Bertolotto, C, Bille, K, Abbe, P, Beuret, L, Busca, R, Flori, E, Chiaverini, C, Ballotti, R, Bahadoran, P, Ortonne, JP	J Biol Chem	2008
25065759	Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport Robinson, C, Montoliu, L, Sviderskaya, EV, Briggs, DA, Tooth, DJ, Evans, RD, Cantero, M, Ramalho, JS, Hume, AN, Patel, S	Curr Biol	2014
18812475	A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion Court, M, Deutsch, E, Fischer, A, Mahlaoui, N, Athman, R, Lambert, N, Ménager, MM, Ménasché, G, Garin, J, de Saint Basile, G, Lefebvre, JM	Blood	2008