Reactome | MITF-M-dependent RAB27A expression

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MITF-M-dependent RAB27A expression Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:5668575] melanosome membrane
created	[InstanceEdit:9856459] Rothfels, Karen, 2023-12-18
dbId	9856460
displayName	MITF-M-dependent RAB27A expression
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens
followingEvent	[Reaction:R-HSA-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9856435] RAB27A gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9732023] Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport [LiteratureReference:9732019] MYO5A Gene Is a Target of MITF in Melanocytes [LiteratureReference:9856425] Rab27a: A key to melanosome transport in human melanocytes [LiteratureReference:9856429] Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport [LiteratureReference:9856394] Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions [LiteratureReference:9856421] Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes [LiteratureReference:9856416] Rab GTPases and myosin motors in organelle motility [LiteratureReference:9856397] Melanosomes on the move: a model to understand organelle dynamics [LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9730403] MITF-the first 25 years
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent RAB27A expression
output	[EntityWithAccessionedSequence:R-HSA-8877281] GGC-RAB27A [melanosome membrane]
precedingEvent	[Reaction:R-HSA-9856466] MITF-M dimer binds RAB27A gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9856456] Positive gene expression regulation by 'MITF-M dimer:RAB27A gene [nucleoplasm]'
regulationReference	[RegulationReference:9856461] Positive gene expression regulation by 'MITF-M dimer:RAB27A gene [nucleoplasm]' Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9856460
summation	[Summation:9856450] RAB27A is a small GTPase with roles in melanosome localizati...

Referrals

(hasEvent)	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation
(precedingEvent)	[Reaction:R-HSA-9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A

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