Reactome | PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients

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PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients Show undefined attributes

authored	[InstanceEdit:9855110] May, Bruce, 2023-11-18
catalystActivity	[CatalystActivity:9855173] mechanosensitive monoatomic cation channel activity of PIEZO1 trimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9855036] May, Bruce, 2023-11-29
dbId	9855089
displayName	PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients
edited	[InstanceEdit:9855110] May, Bruce, 2023-11-18
eventOf	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Homo sapiens
followingEvent	[Reaction:R-HSA-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Homo sapiens [BlackBoxEvent:R-HSA-9858803] MMP14 translocates from the Golgi membrane to the plasma membrane - Homo sapiens [Reaction:R-HSA-9861511] Ca2+ activates Calpain2 (m-Calpain) - Homo sapiens [Reaction:R-HSA-9905999] Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region - Homo sapiens [Reaction:R-HSA-9855161] Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region - Homo sapiens [Reaction:R-HSA-9905934] CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol - Homo sapiens [BlackBoxEvent:R-HSA-9906597] Activation of AKT1 by shear stress in osteocytes - Homo sapiens [BlackBoxEvent:R-HSA-9861331] Secretion of ADM (Adrenomedullin) - Homo sapiens [Reaction:R-HSA-9865215] p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-9860796] Phosphorylation of PDPK1 on serine-241 - Homo sapiens [Reaction:R-HSA-74448] Calcium binds calmodulin - Homo sapiens
inferredFrom	[Reaction:R-MMU-9855091] Piezo1 trimer passively transports cations across the plasma membrane according to their concentration gradients - Mus musculus
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [SimpleEntity:R-ALL-29804] K+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9855099] Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1 [LiteratureReference:9855154] Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
maxDepth	1
modified	[InstanceEdit:9927250] May, Bruce, 2024-11-05
name	PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [SimpleEntity:R-ALL-74126] K+ [extracellular region] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16 [InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9855089
summation	[Summation:9855149] PIEZO1 is a non-selective cation channel that passively tran...
updateTrackers	[UpdateTracker:9928506] Update Tracker - [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928506] Update Tracker - [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells [Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Pathway:R-HSA-9856532] Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
(precedingEvent)	[Reaction:R-HSA-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) [Reaction:R-HSA-9865215] p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane [BlackBoxEvent:R-HSA-9858803] MMP14 translocates from the Golgi membrane to the plasma membrane [Reaction:R-HSA-9861511] Ca2+ activates Calpain2 (m-Calpain) [BlackBoxEvent:R-HSA-9860796] Phosphorylation of PDPK1 on serine-241 [Reaction:R-HSA-9905999] Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region [Reaction:R-HSA-9855161] Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region [Reaction:R-HSA-9905934] CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol [BlackBoxEvent:R-HSA-9906597] Activation of AKT1 by shear stress in osteocytes [BlackBoxEvent:R-HSA-9861331] Secretion of ADM (Adrenomedullin) [Reaction:R-HSA-74448] Calcium binds calmodulin
(inferredTo)	[Reaction:R-MMU-9855091] Piezo1 trimer passively transports cations across the plasma membrane according to their concentration gradients

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