Reactome | PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)

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PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) Show undefined attributes

authored	[InstanceEdit:9864838] May, Bruce, 2024-03-07
catalystActivity	[CatalystActivity:210705] protein tyrosine phosphatase activity of PTPN1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9865219] May, Bruce, 2024-03-09
dbId	9865167
displayName	PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)
edited	[InstanceEdit:9864838] May, Bruce, 2024-03-07
eventOf	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells - Homo sapiens
followingEvent	[Reaction:R-HSA-9865215] p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-HSA-9865224] p-Y24,S26-ANXA2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9865246] Coupling of Integrin ?5 to Annexin A2 by Flow Drives Endothelial Activation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)
orthologousEvent	[Reaction:R-DME-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Drosophila melanogaster [Reaction:R-GGA-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Gallus gallus [Reaction:R-XTR-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Xenopus tropicalis [Reaction:R-SSC-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Sus scrofa [Reaction:R-BTA-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Bos taurus [Reaction:R-CFA-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Canis familiaris [Reaction:R-RNO-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Rattus norvegicus [Reaction:R-MMU-9865167] PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9865163] p-S26-ANXA2 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-71542] Positive regulation by 'Ca2+ [cytosol]'
releaseDate	2024-09-11
requiredInputComponent	[Complex:R-HSA-9855041] PIEZO1 trimer [plasma membrane] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9865167
summation	[Summation:9865159] PTPN1 (PTP1B) interacts with Annexin A2 (Ye et al. 2021) and...

Referrals

(hasEvent)	[Pathway:R-HSA-9860927] Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
(precedingEvent)	[Reaction:R-HSA-9865215] p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane