Reactome | Piezo1 trimer passively transports cations across the plasma membrane according to their concentration gradients

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Piezo1 trimer passively transports cations across the plasma membrane according to their concentration gradients Show undefined attributes

authored	[InstanceEdit:9855036] May, Bruce, 2023-11-29
catalystActivity	[CatalystActivity:9855170] mechanosensitive monoatomic cation channel activity of Piezo1 trimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9855036] May, Bruce, 2023-11-29
dbId	9855091
displayName	Piezo1 trimer passively transports cations across the plasma membrane according to their concentration gradients
edited	[InstanceEdit:9855036] May, Bruce, 2023-11-29
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region] [SimpleEntity:R-ALL-29804] K+ [cytosol] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9855121] Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels [LiteratureReference:9857643] Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone [LiteratureReference:9858436] Direct observation of the conformational states of PIEZO1 [LiteratureReference:9862142] Architecture of the mammalian mechanosensitive Piezo1 channel [LiteratureReference:9862143] A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel [LiteratureReference:9862125] Force-induced conformational changes in PIEZO1 [LiteratureReference:9862169] Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension [LiteratureReference:9862166] Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension [LiteratureReference:9862144] Structure deformation and curvature sensing of PIEZO1 in lipid membranes
maxDepth	1
modified	[InstanceEdit:9927250] May, Bruce, 2024-11-05
name	Piezo1 trimer passively transports cations across the plasma membrane according to their concentration gradients
orthologousEvent	[Reaction:R-HSA-9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients - Homo sapiens
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [SimpleEntity:R-ALL-74126] K+ [extracellular region] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16 [InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9855091
summation	[Summation:9855107] Piezo1 is a non-selective cation channel that passively tran...

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