Reactome | OGDH complex synthesizes succinyl-CoA from 2-OG

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OGDH complex synthesizes succinyl-CoA from 2-OG Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049006
displayName	OGDH complex synthesizes succinyl-CoA from 2-OG
eventOf	[Pathway:R-DDI-71403] Citric acid cycle (TCA cycle) - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2455429] succinyl-CoA biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-71401] OGDH dimer decarboxylates 2-OG - Dictyostelium discoideum [Reaction:R-DDI-9853512] DLST transfers succinyl to CoA - Dictyostelium discoideum [Reaction:R-DDI-9853499] DLD dimer dehydrogenates dihydrolipoyl - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	OGDH complex synthesizes succinyl-CoA from 2-OG Succinyl-CoA Biosynthesis alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-9853506
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-71403] Citric acid cycle (TCA cycle)
(inferredTo)	[Pathway:R-HSA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG

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