Reactome | Active LTK binds GRB2:TNK2

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Active LTK binds GRB2:TNK2 Show undefined attributes

authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId	9842665
displayName	Active LTK binds GRB2:TNK2
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9842663] Signaling by LTK - Homo sapiens
input	[Complex:R-HSA-9842589] GRB2:TNK2 [cytosol] [Complex:R-HSA-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9842489] Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling [LiteratureReference:9842507] An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway [LiteratureReference:9842473] Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase [LiteratureReference:9842484] Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1 [LiteratureReference:9842435] Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas [LiteratureReference:9842483] Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Active LTK binds GRB2:TNK2
orthologousEvent	[BlackBoxEvent:R-GGA-9842665] Active LTK binds GRB2:TNK2 - Gallus gallus [BlackBoxEvent:R-RNO-9842665] Active LTK binds GRB2:TNK2 - Rattus norvegicus [BlackBoxEvent:R-MMU-9842665] Active LTK binds GRB2:TNK2 - Mus musculus
output	[Complex:R-HSA-9842598] Active LTK:GRB2:TNK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9842648] Autophosphorylation of LTK dimer:ALKAL1,2 - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9842665
summation	[Summation:9842670] Full-length LTK binds to the cytoplasmic tyrosine kinase TNK...

Referrals

(hasEvent)

[Pathway:R-HSA-9842663] Signaling by LTK