Reactome | Active LTK binds GRB2:TNK2

Active LTK binds GRB2:TNK2

Stable Identifier

R-HSA-9842665

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

3/5

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Full-length LTK binds to the cytoplasmic tyrosine kinase TNK2 (also known as ACK) indirectly through GRB2 (Pao-Chun et al, 2009). It is possible that this interaction is promoted by one or both of the two NPXY sites in LTK that are believed to recruit GRB2 (Y485, through IRS1 or Y862 through SHC1), but this has not been tested (Ueno et al, 1995; Ueno et al, 1996). In other contexts, TNK2 contributes to cell spreading, metastasis and migration, but its possible role in LTK signaling remains to be clarified (Lougheed et al, 2004; Eisenmann et al, 1999; Modzelewska et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
8910363	Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase Yazaki, Y, Mitani, K, Miyagawa, K, Kozutsumi, H, Hirai, H, Sasaki, K, Ueno, H	J Biol Chem	1996
19815557	Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling Chan, PM, Pao-Chun, L, Manser, E, Chan, W	J Biol Chem	2009
7650032	An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway Yazaki, Y, Hirano, N, Kozutsumi, H, Tanaka, T, Hirai, H, Sasaki, K, Ueno, H	J Biol Chem	1995
17038317	Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas Newman, LP, Keely, PJ, Modzelewska, K, Desai, R	J Biol Chem	2006
10587647	Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas Guan, JL, Simpson, MA, Lim, L, Manser, E, Keely, PJ, Iida, J, McCarthy, JB, Furcht, LT, Eisenmann, KM, Tachibana, K	Nat Cell Biol	1999
15308621	Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1 Chen, RH, Mak, P, Lougheed, JC, Stout, TJ	J Biol Chem	2004