Full-length LTK binds to the cytoplasmic tyrosine kinase TNK...

created [InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
dbId 9842670
displayName Full-length LTK binds to the cytoplasmic tyrosine kinase TNK...
modified [InstanceEdit:9845074] Rothfels, Karen, 2023-09-26
schemaClass Summation
text Full-length LTK binds to the cytoplasmic tyrosine kinase TNK2 (also known as ACK) indirectly through GRB2 (Pao-Chun et al, 2009). It is possible that this interaction is promoted by one or both of the two NPXY sites in LTK that are believed to recruit GRB2 (Y485, through IRS1 or Y862 through SHC1), but this has not been tested (Ueno et al, 1995; Ueno et al, 1996). In other contexts, TNK2 contributes to cell spreading, metastasis and migration, but its possible role in LTK signaling remains to be clarified (Lougheed et al, 2004; Eisenmann et al, 1999; Modzelewska et al, 2006).
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