Reactome | Active LTK binds GRB2:TNK2

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10217774
displayName	Active LTK binds GRB2:TNK2
eventOf	[Pathway:R-RNO-9842663] Signaling by LTK - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9842665] Active LTK binds GRB2:TNK2 - Homo sapiens
input	[Complex:R-RNO-9842589] GRB2:TNK2 [cytosol] [Complex:R-RNO-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Active LTK binds GRB2:TNK2
output	[Complex:R-RNO-9842598] Active LTK:GRB2:TNK2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-9842648] Autophosphorylation of LTK dimer:ALKAL1,2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9842665
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-9842663] Signaling by LTK
(inferredTo)	[BlackBoxEvent:R-HSA-9842665] Active LTK binds GRB2:TNK2

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