Reactome | p-5Y LTK dimer:ALKAL1,2 [plasma membrane]

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9842596] p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] - Homo sapiens [Complex:R-HSA-9842598] Active LTK:GRB2:TNK2 [plasma membrane] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-9842665] Active LTK binds GRB2:TNK2 - Homo sapiens [Reaction:R-HSA-9842649] Active LTK receptor binds PI3K - Homo sapiens [Reaction:R-HSA-9842671] Active LTK binds IRS1 - Homo sapiens [Reaction:R-HSA-9842641] Active LTK receptor binds SHC1 - Homo sapiens
created	[InstanceEdit:9842605] Rothfels, Karen, 2023-08-27
dbId	9842590
displayName	p-5Y LTK dimer:ALKAL1,2 [plasma membrane]
hasComponent	[DefinedSet:R-HSA-9842609] ALKAL1,2 [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-9842578] p-6Y-LTK [plasma membrane]
inDisease	false
includedLocation	[Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane] - Mus musculus [Complex:R-RNO-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane] - Rattus norvegicus [Complex:R-DRE-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane] - Danio rerio [Complex:R-XTR-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-9842590] p-5Y LTK dimer:ALKAL1,2 [plasma membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:9842437] Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome
maxDepth	3
name	p-5Y LTK dimer:ALKAL1,2
producedByEvent	[Reaction:R-HSA-9842648] Autophosphorylation of LTK dimer:ALKAL1,2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9842590

(hasComponent)	[Complex:R-HSA-9842598] Active LTK:GRB2:TNK2 [plasma membrane] [Complex:R-HSA-9842596] p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] [Complex:R-HSA-9842607] Active LTK:p-3Y SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9842606] Active LTK:p-3Y SHC1 [plasma membrane] [Complex:R-HSA-9842595] Active LTK:p-Y IRS1:GRB2 [plasma membrane] [Complex:R-HSA-9842601] Active LTK:p-Y IRS1 [plasma membrane] [Complex:R-HSA-9842600] Active LTK:IRS1 [plasma membrane] [Complex:R-HSA-9842592] Active LTK:SHC1 [plasma membrane]
(input)	[BlackBoxEvent:R-HSA-9842665] Active LTK binds GRB2:TNK2 [Reaction:R-HSA-9842649] Active LTK receptor binds PI3K [Reaction:R-HSA-9842671] Active LTK binds IRS1 [Reaction:R-HSA-9842641] Active LTK receptor binds SHC1
(output)	[Reaction:R-HSA-9842648] Autophosphorylation of LTK dimer:ALKAL1,2

p-5Y LTK dimer:ALKAL1,2 [plasma membrane] Show undefined attributes

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