Reactome | Polyubiquitination of substrate

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Polyubiquitination of substrate Show undefined attributes

catalystActivity	[CatalystActivity:10596245] ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10596247
displayName	Polyubiquitination of substrate
eventOf	[Pathway:R-GGA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-983147] Release of E3 from polyubiquitinated substrate - Gallus gallus
inferredFrom	[BlackBoxEvent:R-HSA-983156] Polyubiquitination of substrate - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-GGA-983131] E3:Ub:substrate [cytosol] 2 × [Complex:R-GGA-976165] Ubiquitin:E2 conjugating enzymes [cytosol]
isInDisease	false
isInferred	true
name	Polyubiquitination of substrate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] 2 × [CandidateSet:R-GGA-947628] E2 Ubiquitin-conjugating enzyme [cytosol] [Complex:R-GGA-983134] E3:K48-polyubiquitinated substrate [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-GGA-983140] Transfer of Ub from E2 to substrate and release of E2 - Gallus gallus
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-983156
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[Reaction:R-GGA-983147] Release of E3 from polyubiquitinated substrate
(inferredTo)	[BlackBoxEvent:R-HSA-983156] Polyubiquitination of substrate