Reactome | Transfer of Ub from E2 to substrate and release of E2

Schema > Reaction > Entries

Transfer of Ub from E2 to substrate and release of E2 Show undefined attributes

catalystActivity	[CatalystActivity:10592090] ubiquitin-protein transferase activity of E3 ligases in proteasomal degradation [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10592092
displayName	Transfer of Ub from E2 to substrate and release of E2
eventOf	[Pathway:R-DRE-983168] Antigen processing: Ubiquitination & Proteasome degradation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DRE-983156] Polyubiquitination of substrate - Danio rerio
inferredFrom	[Reaction:R-HSA-983140] Transfer of Ub from E2 to substrate and release of E2 - Homo sapiens
input	[Complex:R-DRE-983126] Ag-substrate:E3:E2:Ub [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Transfer of Ub from E2 to substrate and release of E2
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [CandidateSet:R-DRE-947628] E2 Ubiquitin-conjugating enzyme [cytosol] [Complex:R-DRE-983131] E3:Ub:substrate [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-DRE-983157] Interaction of E3 with substrate and E2-Ub complex - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-983140
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[BlackBoxEvent:R-DRE-983156] Polyubiquitination of substrate
(inferredTo)	[Reaction:R-HSA-983140] Transfer of Ub from E2 to substrate and release of E2

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