Reactome | Growth hormone receptor signaling

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Growth hormone receptor signaling Show undefined attributes

authored	[InstanceEdit:976955] Jupe, S, 2010-10-14
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:982796] Jupe, S, 2010-10-28
crossReference	[DatabaseIdentifier:12819653] BioModels Database:BIOMD0000001077 [DatabaseIdentifier:12819655] BioModels Database:BIOMD0000000314 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313
dbId	982772
displayName	Growth hormone receptor signaling
edited	[InstanceEdit:1362504] Jupe, S, 2011-06-10
eventOf	[Pathway:R-HSA-1280215] Cytokine Signaling in Immune system - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:396537] growth hormone receptor signaling pathway via JAK-STAT
hasDiagram	true
hasEHLD	false
hasEvent	[Polymerisation:R-HSA-982765] Growth hormone forms dimers and oligomers - Homo sapiens [Reaction:R-HSA-982792] Growth hormone receptor binds JAK2 - Homo sapiens [Reaction:R-HSA-982775] Growth hormone receptor dimerizes - Homo sapiens [Reaction:R-HSA-982778] Growth hormone binds the growth hormone receptor - Homo sapiens [BlackBoxEvent:R-HSA-982768] GH:GHR:JAK2 complex undergoes a conformational change - Homo sapiens [BlackBoxEvent:R-HSA-982810] JAK2 phosphorylation - Homo sapiens [Reaction:R-HSA-1168423] JAK2 phosphorylation of IRS-1/2 - Homo sapiens [Reaction:R-HSA-982807] JAK2 phosphorylation of GHR - Homo sapiens [Reaction:R-HSA-1168393] STAT5 association with GHR - Homo sapiens [Reaction:R-HSA-1168394] STAT5 tyrosine phosphorylation - Homo sapiens [Reaction:R-HSA-1168894] p-STAT5A/B dissociates from the Growth Hormone receptor - Homo sapiens [Reaction:R-HSA-452102] p-STAT5 dimerizes - Homo sapiens [BlackBoxEvent:R-HSA-507937] STAT5 dimers translocate to the nucleus - Homo sapiens [Reaction:R-HSA-1168456] Growth hormone receptor binds Lyn - Homo sapiens [BlackBoxEvent:R-HSA-1168459] Lyn activates ERK - Homo sapiens [Reaction:R-HSA-1168768] JAK2 binds STAT1/3 - Homo sapiens [Reaction:R-HSA-1168767] JAK2 phosphorylates STAT1/STAT3 - Homo sapiens [Reaction:R-HSA-1168809] SOCS binding to GHR - Homo sapiens [Reaction:R-HSA-1168813] SOCS binding to JAK2 - Homo sapiens [Reaction:R-HSA-1168445] PTP1B binds the GH receptor complex - Homo sapiens [Reaction:R-HSA-1169192] PTP1B dephosphorylates GHR - Homo sapiens [Reaction:R-HSA-1169210] PTP1B dephosphorylates JAK2 - Homo sapiens [Reaction:R-HSA-1168839] SHP1 (PTPN6) binds JAK2 in the receptor complex - Homo sapiens [Reaction:R-HSA-1169188] SHP1 (PTPN6) dephosphorylates JAK2 - Homo sapiens [Reaction:R-HSA-1168777] Metalloprotease cleavage of GHR - Homo sapiens [Reaction:R-HSA-1362485] GHBP binds GH - Homo sapiens [Reaction:R-HSA-1362465] GHBP binds GHR - Homo sapiens [BlackBoxEvent:R-HSA-1168789] GHR internalization - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:1168415] The growth hormone receptor: mechanism of activation and clinical implications [LiteratureReference:982825] Growth hormone receptor: structure and signal transduction [LiteratureReference:982766] In vivo analysis of growth hormone receptor signaling domains and their associated transcripts [LiteratureReference:1169265] Determinants of growth hormone receptor down-regulation
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Growth hormone receptor signaling
orthologousEvent	[Pathway:R-MMU-982772] Growth hormone receptor signaling - Mus musculus [Pathway:R-RNO-982772] Growth hormone receptor signaling - Rattus norvegicus [Pathway:R-CFA-982772] Growth hormone receptor signaling - Canis familiaris [Pathway:R-BTA-982772] Growth hormone receptor signaling - Bos taurus [Pathway:R-SSC-982772] Growth hormone receptor signaling - Sus scrofa [Pathway:R-DRE-982772] Growth hormone receptor signaling - Danio rerio [Pathway:R-XTR-982772] Growth hormone receptor signaling - Xenopus tropicalis [Pathway:R-GGA-982772] Growth hormone receptor signaling - Gallus gallus
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1363241] Herington, AC, 2011-06-13 [InstanceEdit:1364056] Waters, MJ, 2011-06-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-982772
summation	[Summation:1169268] Growth hormone (Somatotropin or GH) is a key factor in deter...
updateTrackers	[UpdateTracker:9788604] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v41:[updateContainedRLE] [UpdateTracker:9779194] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v66:[updateContainedRLE] [UpdateTracker:9789003] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v39:[updateContainedRLE] [UpdateTracker:9775936] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v78:[updateContainedRLE] [UpdateTracker:9781454] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v61:[updateContainedRLE] [UpdateTracker:9787042] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v46:[updateContainedRLE] [UpdateTracker:9780242] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v63:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-1280215] Cytokine Signaling in Immune system

(updatedInstance)

[UpdateTracker:9788604] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v41:[updateContainedRLE]
[UpdateTracker:9779194] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v66:[updateContainedRLE]
[UpdateTracker:9789003] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v39:[updateContainedRLE]
[UpdateTracker:9775936] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v78:[updateContainedRLE]
[UpdateTracker:9781454] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v61:[updateContainedRLE]
[UpdateTracker:9787042] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v46:[updateContainedRLE]
[UpdateTracker:9780242] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v63:[updateContainedRLE]

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