Reactome | JAK2 phosphorylates STAT1/STAT3

Schema > Reaction > Entries

JAK2 phosphorylates STAT1/STAT3 Show undefined attributes

authored	[InstanceEdit:976955] Jupe, S, 2010-10-14
catalystActivity	[CatalystActivity:1169203] non-membrane spanning protein tyrosine kinase activity of Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1168782] Jupe, S, 2011-01-07
dbId	1168767
displayName	JAK2 phosphorylates STAT1/STAT3
edited	[InstanceEdit:1362504] Jupe, S, 2011-06-10
eventOf	[Pathway:R-HSA-982772] Growth hormone receptor signaling - Homo sapiens
inferredFrom	[Reaction:R-MMU-1169206] Jak2 phosphorylates Stat1/Stat3 - Mus musculus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1169146] Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 phosphorylates STAT1/STAT3
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1169186] Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:p(Y701)-STAT1/p(Y705)-STAT3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1168768] JAK2 binds STAT1/3 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1363241] Herington, AC, 2011-06-13 [InstanceEdit:1364056] Waters, MJ, 2011-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1168767
summation	[Summation:1168780] GH stimulated tyrosyl phosphorylation of Stats 1, 3, and 5 i...

Referrals

(hasEvent)	[Pathway:R-HSA-982772] Growth hormone receptor signaling
(inferredTo)	[Reaction:R-MMU-1169206] Jak2 phosphorylates Stat1/Stat3

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