Reactome | STAT5 association with GHR

Schema > Reaction > Entries

authored	[InstanceEdit:976955] Jupe, S, 2010-10-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1168386] Jupe, S, 2010-12-20
dbId	1168393
displayName	STAT5 association with GHR
edited	[InstanceEdit:1362504] Jupe, S, 2011-06-10
eventOf	[Pathway:R-HSA-982772] Growth hormone receptor signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-1168394] STAT5 tyrosine phosphorylation - Homo sapiens
inferredFrom	[Reaction:R-MMU-1168910] Stat5 association with Ghr - Mus musculus
input	[Complex:R-HSA-1168898] Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] [DefinedSet:R-HSA-452094] STAT5A,STAT5B [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STAT5 association with GHR
output	[Complex:R-HSA-1168902] Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane]
precedingEvent	[Reaction:R-HSA-982807] JAK2 phosphorylation of GHR - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1363241] Herington, AC, 2011-06-13 [InstanceEdit:1364056] Waters, MJ, 2011-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1168393
summation	[Summation:1168426] JAK2 is required for GH-mediated phosphorylation of STATs 1,...

(precedingEvent)	[Reaction:R-HSA-1168394] STAT5 tyrosine phosphorylation
(hasEvent)	[Pathway:R-HSA-982772] Growth hormone receptor signaling
(inferredTo)	[Reaction:R-MMU-1168910] Stat5 association with Ghr

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