Reactome | JAK2 phosphorylation of IRS-1/2

Schema > Reaction > Entries

authored	[InstanceEdit:976955] Jupe, S, 2010-10-14
catalystActivity	[CatalystActivity:1168883] non-membrane spanning protein tyrosine kinase activity of Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1168430] Jupe, S, 2010-12-21
dbId	1168423
displayName	JAK2 phosphorylation of IRS-1/2
edited	[InstanceEdit:1362504] Jupe, S, 2011-06-10
eventOf	[Pathway:R-HSA-982772] Growth hormone receptor signaling - Homo sapiens
inferredFrom	[Reaction:R-RNO-1168854] JAK2 phosphorylation of Irs-1/2 - Rattus norvegicus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-198273] IRS1,2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 phosphorylation of IRS-1/2
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-112322] p-Y-IRS1,p-Y-IRS2 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-982810] JAK2 phosphorylation - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1363241] Herington, AC, 2011-06-13 [InstanceEdit:1364056] Waters, MJ, 2011-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1168423
summation	[Summation:1168429] GH has short term effects that mimic the actions of insulin...

(hasEvent)	[Pathway:R-HSA-982772] Growth hormone receptor signaling
(inferredTo)	[Reaction:R-RNO-1168854] JAK2 phosphorylation of Irs-1/2

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