Reactome | Growth hormone receptor dimerizes

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Growth hormone receptor dimerizes Show undefined attributes

authored	[InstanceEdit:976955] Jupe, S, 2010-10-14
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:982796] Jupe, S, 2010-10-28
dbId	982775
displayName	Growth hormone receptor dimerizes
edited	[InstanceEdit:1362504] Jupe, S, 2011-06-10
eventOf	[Pathway:R-HSA-982772] Growth hormone receptor signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-982778] Growth hormone binds the growth hormone receptor - Homo sapiens
input	2 × [Complex:R-HSA-982774] Growth Hormone Receptor:JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:982786] Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Growth hormone receptor dimerizes
orthologousEvent	[Reaction:R-GGA-982775] Growth hormone receptor dimerizes - Gallus gallus [Reaction:R-DRE-982775] Growth hormone receptor dimerizes - Danio rerio [Reaction:R-RNO-982775] Growth hormone receptor dimerizes - Rattus norvegicus [Reaction:R-MMU-982775] Growth hormone receptor dimerizes - Mus musculus
output	[Complex:R-HSA-982764] Growth Hormone Receptor-JAK2 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-982792] Growth hormone receptor binds JAK2 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-1362495] Negative regulation by 'GHBP:GHR [plasma membrane]'
regulationReference	[RegulationReference:9642925] Negative regulation by 'GHBP:GHR [plasma membrane]' A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1363241] Herington, AC, 2011-06-13 [InstanceEdit:1364056] Waters, MJ, 2011-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-982775
summation	[Summation:982800] The growth hormone receptor forms dimers (Cunningham et al. ...
updateTrackers	[UpdateTracker:9775869] Update Tracker - [Reaction:982775] Growth hormone receptor dimerizes - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775869] Update Tracker - [Reaction:982775] Growth hormone receptor dimerizes - v78:[modifyText]
(hasEvent)	[Pathway:R-HSA-982772] Growth hormone receptor signaling
(precedingEvent)	[Reaction:R-HSA-982778] Growth hormone binds the growth hormone receptor

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