Reactome | OPTN, TBK1 bind ubiquitinated MOM proteins

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OPTN, TBK1 bind ubiquitinated MOM proteins Show undefined attributes

category	binding
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10725140
displayName	OPTN, TBK1 bind ubiquitinated MOM proteins
eventOf	[Pathway:R-XTR-5205685] PINK1-PRKN Mediated Mitophagy - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Homo sapiens
input	[DefinedSet:R-XTR-9824893] K63polyUb-MOM proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-XTR-9687907] optn [cytosol] [EntityWithAccessionedSequence:R-XTR-166267] TBK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	OPTN, TBK1 bind ubiquitinated MOM proteins
output	[Complex:R-XTR-9824896] TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9824888
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5205685] PINK1-PRKN Mediated Mitophagy
(precedingEvent)	[Reaction:R-XTR-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
(inferredTo)	[Reaction:R-HSA-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins

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