Reactome | IKK? (IKBKE) is phosphorylated within the activated TLR4 complex

Schema > Reaction > Entries

IKK? (IKBKE) is phosphorylated within the activated TLR4 complex Show undefined attributes

authored	[InstanceEdit:9823790] Shamovsky, Veronica, 2023-01-10
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9824881] Shamovsky, Veronica, 2023-01-23
dbId	9824882
displayName	IKK? (IKBKE) is phosphorylated within the activated TLR4 complex
edited	[InstanceEdit:9863317] Shamovsky, Veronica, 2024-02-28
eventOf	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Homo sapiens
followingEvent	[Reaction:R-HSA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9823936] IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IKK? (IKBKE) is phosphorylated within the activated TLR4 complex IKBKE is phosphorylated within IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14
orthologousEvent	[Reaction:R-GGA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Gallus gallus [Reaction:R-DRE-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Danio rerio [Reaction:R-SSC-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Sus scrofa [Reaction:R-BTA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Bos taurus [Reaction:R-CFA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Canis familiaris [Reaction:R-RNO-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Rattus norvegicus [Reaction:R-MMU-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-HSA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863305] Muniti?, Ivana, 2024-02-28 [InstanceEdit:9863304] Franjki?, Toni, 2024-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9824882
summation	[Summation:9824883] Inhibitor of kappaB kinase epsilon (IKK?, IKBKE) and its clo...

Referrals

(hasEvent)	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(precedingEvent)	[Reaction:R-HSA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4

Cite Us!