Reactome | IKK? (IKBKE) is phosphorylated within the activated TLR4 complex

Schema > Reaction > Entries

IKK? (IKBKE) is phosphorylated within the activated TLR4 complex Show undefined attributes

category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10323813
displayName	IKK? (IKBKE) is phosphorylated within the activated TLR4 complex
eventOf	[Pathway:R-CFA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-9823936] IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IKK? (IKBKE) is phosphorylated within the activated TLR4 complex IKBKE is phosphorylated within IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-CFA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9824882
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
(precedingEvent)	[Reaction:R-CFA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
(inferredTo)	[Reaction:R-HSA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex

Cite Us!