Reactome | Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Schema > Reaction > Entries

Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 Show undefined attributes

authored	[InstanceEdit:9823790] Shamovsky, Veronica, 2023-01-10
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9823930] Shamovsky, Veronica, 2023-01-12
dbId	9823932
deleted	[Deleted:9863359] Deletion of instance: 936941 [Deleted:3371608] Deletion of instance: 168926
displayName	Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
edited	[InstanceEdit:9863317] Shamovsky, Veronica, 2024-02-28
eventOf	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9823939] IKK? (IKBKE) is ubiquitinated within the activated TLR4 - Homo sapiens [Reaction:R-HSA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-450225] IKBKE [cytosol] [Complex:R-HSA-5362507] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
orthologousEvent	[Reaction:R-GGA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Gallus gallus [Reaction:R-SSC-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Sus scrofa [Reaction:R-BTA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Bos taurus [Reaction:R-CFA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Canis familiaris [Reaction:R-RNO-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Rattus norvegicus [Reaction:R-MMU-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Mus musculus
output	[Complex:R-HSA-9823936] IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Homo sapiens
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863305] Muniti?, Ivana, 2024-02-28 [InstanceEdit:9863304] Franjki?, Toni, 2024-02-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9823932
summation	[Summation:9823937] Pathogen-induced inflammatory signaling pathways lead to the...

Referrals

(replacementInstances)	[Deleted:9863359] Deletion of instance: 936941 [Deleted:3371608] Deletion of instance: 168926
(precedingEvent)	[BlackBoxEvent:R-HSA-9823939] IKK? (IKBKE) is ubiquitinated within the activated TLR4 [Reaction:R-HSA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex
(hasEvent)	[Pathway:R-HSA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)