Reactome | p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

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p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9824881] Shamovsky, Veronica, 2023-01-23
dbId	9824884
displayName	p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
hasComponent	[Complex:R-HSA-5362507] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-HSA-9730458] p-S172-IKBKE:p-S172-IKBKE [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
inferredTo	[Complex:R-MMU-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Mus musculus [Complex:R-RNO-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Rattus norvegicus [Complex:R-CFA-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Canis familiaris [Complex:R-BTA-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Bos taurus [Complex:R-SSC-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Sus scrofa [Complex:R-DRE-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Danio rerio [Complex:R-GGA-9824884] p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:2423800] Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling [LiteratureReference:5362506] Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF [LiteratureReference:2423829] Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
maxDepth	8
memberOf	[DefinedSet:R-HSA-936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] - Homo sapiens
name	p-S172-IKBKE:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-S172-IKBKE
producedByEvent	[Reaction:R-HSA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9824884

Referrals

(output)	[Reaction:R-HSA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex
(hasMember)	[DefinedSet:R-HSA-936970] activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane]

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