Reactome | FOXA2 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

FOXA2 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9823834] p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9793593] FOXA2:CDH1 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9823744] TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9823836] SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene - Homo sapiens [Reaction:R-HSA-9765371] FOXA2 binds CDH1 gene promoter - Homo sapiens [Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene - Homo sapiens
created	[InstanceEdit:211281] D'Eustachio, P, 2008-01-29 21:29:33
dbId	211275
displayName	FOXA2 [nucleoplasm]
endCoordinate	457
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-211275] Foxa2 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-211275] Foxa2 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-211275] FOXA2 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-211275] FOXA2 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-211275] FOXA2 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-211275] foxa2 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-GGA-211275] FOXA2 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-211275] fkh [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-211275] pha-4 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-SPO-211275] mei4 [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SPO-211275-2] sep1 [nucleoplasm] - Schizosaccharomyces pombe [DefinedSet:R-SPO-211275-3] Homologues of FOXA2 [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-211275] HCM1 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-211275-2] FKH1 [nucleoplasm] - Saccharomyces cerevisiae [DefinedSet:R-SCE-211275-3] Homologues of FOXA2 [nucleoplasm] - Saccharomyces cerevisiae
markingReferences	[MarkerReference:9910735] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909351] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909324] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909332] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9921105] FOXA2 [nucleoplasm] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921570] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9910708] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909338] FOXA2 [nucleoplasm] FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner
maxDepth	1
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	FOXA2 FOXOA2
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-211277] Positive gene expression regulation by 'FOXA2 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-9823989] Expression of FOXA2 in definitive endoderm - Homo sapiens [BlackBoxEvent:R-HSA-9796209] Expression of FOXA2 in the anterior primitive streak - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q9Y261] UniProt:Q9Y261 FOXA2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-211275
startCoordinate	1
updateTrackers	[UpdateTracker:9882365] Update Tracker - [EntityWithAccessionedSequence:211275] FOXA2 [nucleoplasm] - v45:[addName] [UpdateTracker:9879944] Update Tracker - [EntityWithAccessionedSequence:211275] FOXA2 [nucleoplasm] - v44:[modifyEndCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9882365] Update Tracker - [EntityWithAccessionedSequence:211275] FOXA2 [nucleoplasm] - v45:[addName] [UpdateTracker:9879944] Update Tracker - [EntityWithAccessionedSequence:211275] FOXA2 [nucleoplasm] - v44:[modifyEndCoordinate]
(proteinMarker)	[Cell:R-HSA-9910606] pancreatic pro-acinar cell [Cell:R-HSA-9909345] pancretic tip progenitor cell [Cell:R-HSA-9907637] dorsal foregut endoderm cell [Cell:R-HSA-9909315] duodeno-pancreatic endoderm cell [Cell:R-HSA-9911207] definitive endoderm cell [Cell:R-HSA-9911211] ventral foregut endoderm cell [Cell:R-HSA-9910609] pancreatic trunk bipotent progenitor cell [Cell:R-HSA-9909323] primary multipotent pancreatic progenitor cell
(marker)	[MarkerReference:9910735] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909351] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909324] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909332] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9921105] FOXA2 [nucleoplasm] Efficient differentiation of human embryonic stem cells to definitive endoderm [MarkerReference:9921570] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9910708] FOXA2 [nucleoplasm] Development of the human pancreas from foregut to endocrine commitment [MarkerReference:9909338] FOXA2 [nucleoplasm] FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner
(input)	[Reaction:R-HSA-9823836] SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene [Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene [Reaction:R-HSA-9765371] FOXA2 binds CDH1 gene promoter
(hasComponent)	[Complex:R-HSA-9823834] p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm] [Complex:R-HSA-9823744] TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] [Complex:R-HSA-9793593] FOXA2:CDH1 gene [nucleoplasm]
(activeUnit)	[PositiveGeneExpressionRegulation:9823851] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4:FOXA2:TBXT:GATA6:GATA4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9793592] Positive gene expression regulation by 'FOXA2:CDH1 gene [nucleoplasm]'
(output)	[BlackBoxEvent:R-HSA-9823989] Expression of FOXA2 in definitive endoderm [BlackBoxEvent:R-HSA-9796209] Expression of FOXA2 in the anterior primitive streak
(regulator)	[PositiveGeneExpressionRegulation:R-HSA-211277] Positive gene expression regulation by 'FOXA2 [nucleoplasm]'

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