Reactome | ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens

Schema > Reaction > Entries

ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens Show undefined attributes

catalystActivity	[CatalystActivity:10372299] beta-galactoside alpha-2,6-sialyltransferase activity of ST6GAL1 [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10372474
displayName	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
eventOf	[Pathway:R-BTA-977068] Termination of O-glycan biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens - Homo sapiens
input	[SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen] [DefinedSet:R-BTA-913659] Tn antigens [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position
output	[SimpleEntity:R-ALL-727810] CMP [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-BTA-1463504] Sialyl Tn antigens [Golgi lumen]
precedingEvent	[Reaction:R-BTA-913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-977071
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-977068] Termination of O-glycan biosynthesis
(inferredTo)	[Reaction:R-HSA-977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens

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