ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens

Stable Identifier
Reaction [transition]
Homo sapiens
Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position
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Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) transfers sialic acid (Neu5Ac) from the donor CMP-Neu5Ac to galactose-containing acceptor substrates such as Tn antigens (Stamenkovic et al. 1990, Marcos et al. 2004). The resultant sialyl Tn antigens are highly expressed in several human carcinomas and are associated with carcinoma aggressiveness and poor prognosis (Sewell et al. 2006, Lakshmanan et al. 2021).
Literature References
PubMed ID Title Journal Year
15466199 Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen

Almeida, R, Costa, J, Morais, V, Clausen, H, Kihlberg, J, Grandela, C, Reis, CA, Samyn-Petit, B, Marcos, NT, Cruz, A, Harduin-Lepers, A, Pinho, S, Silva, F

Cancer Res 2004
2373995 The B cell antigen CD75 is a cell surface sialytransferase

Blomhoff, HK, Funderud, S, Stamenkovic, I, Smeland, EB, Asheim, HC, Deggerdal, A

J Exp Med 1990
16319059 The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer

Burchell, J, Bäckström, M, Karlsson, H, Sewell, R, Gätgens, J, Hansson, GC, Noll, T, Gschmeissner, S, Dalziel, M, Taylor-Papadimitriou, J, Clausen, H

J Biol Chem 2006
Catalyst Activity

beta-galactoside alpha-2,6-sialyltransferase activity of ST6GAL1 [Golgi membrane]

Orthologous Events
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