Reactome | AcK-NFE2L2, CHD6 and MAFK bind NQO1 gene

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AcK-NFE2L2, CHD6 and MAFK bind NQO1 gene Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9759144] Rothfels, Karen, 2021-11-29
dbId	9759141
displayName	AcK-NFE2L2, CHD6 and MAFK bind NQO1 gene
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily - Homo sapiens [Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9759186] AcK-NFE2L2- dependent NQO1 gene expression - Homo sapiens
inferredFrom	[Reaction:R-NUL-9759143] Nfe2L2 and MafK bind Nqo1 gene - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9944065] CHD6 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1008242] MAFK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9759080] NQO1 gene [nucleoplasm] [Complex:R-HSA-9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9759299] Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice [LiteratureReference:9759274] Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9758970] An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements [LiteratureReference:9759034] The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes [LiteratureReference:9944228] The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
maxDepth	1
modified	[InstanceEdit:9974211] Rothfels, Karen, 2025-11-20
name	AcK-NFE2L2, CHD6 and MAFK bind NQO1 gene
output	[Complex:R-HSA-9759114] NQO1 gene:p-AcK-NFE2L2:CHD6:MAFK [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9760081] CREBBP, EP300 acetylates NFE2L2 - Homo sapiens [Reaction:R-HSA-9708557] FBXL17 binds BACH1:MAFK - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9759141
summation	[Summation:9759140] The NQO1 gene encodes an NAD(P)H dehydrogenase quinone 1 enz...
updateTrackers	[UpdateTracker:9953550] Update Tracker - [Reaction:9759141] AcK-NFE2L2, CHD6 and MAFK bind NQO1 gene - v93:[modifyText, removeInput, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9953550] Update Tracker - [Reaction:9759141] AcK-NFE2L2, CHD6 and MAFK bind NQO1 gene - v93:[modifyText, removeInput, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily [Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes
(precedingEvent)	[BlackBoxEvent:R-HSA-9759186] AcK-NFE2L2- dependent NQO1 gene expression
(inferredTo)	[Reaction:R-NUL-9759143] Nfe2L2 and MafK bind Nqo1 gene