AcK-NFE2L2 and MAFK bind NQO1 gene

Stable Identifier
Reaction [binding]
Homo sapiens
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The NQO1 gene encodes an NAD(P)H dehydrogenase quinone 1 enzyme. NQO1 is one of a number of drug metabolism genes upregulated by the NFE2L2:KEAP1 pathway in response to oxidative stress and a chemically diverse group of compounds now known as "phase II inducers" (Rangsamy et al, 2004; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2000). NFE2L2 binds to the anti-oxidant response element (ARE) as a heterodimer with small MAF proteins like MAFK and upregulates NQO1 expression (Itoh et al, 1997; McMahon et al, 2001; Rangasamy et al, 2004; Malhotra et al, 2010). Binding and transcriptional activation by NFE2L2 at the NQO1 promoter is enhanced by CREBBP or EP300-mediated acetylation of NFE2L2 at 18 sites in the N-terminal Neh1 domain (Sun et al, 2009).
Literature References
PubMed ID Title Journal Year
11309284 The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K

Cancer Res 2001
9240432 An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Ishii, T, Hatayama, I, Nabeshima, Y, Yamamoto, M, Takahashi, S, Satoh, K, Oyake, T, Hayashi, N, Igarashi, K, Itoh, K, Chiba, T, Katoh, Y

Biochem Biophys Res Commun 1997
20460467 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Shyr, C, Srivastava, S, Wakabayashi, N, Wasserman, WW, Singh, A, Malhotra, D, Biswal, S, Happel, C, Portales-Casamar, E, Kensler, TW, Arenillas, D

Nucleic Acids Res 2010
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
15520857 Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

Yamamoto, M, Srisuma, SS, Cho, CY, Zhen, L, Biswal, S, Thimmulappa, RK, Rangasamy, T, Petrache, I, Kensler, TW, Tuder, RM

J Clin Invest 2004
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