The NQO1 gene encodes an NAD(P)H dehydrogenase quinone 1 enzyme. NQO1 is one of a number of drug metabolism genes upregulated by the NFE2L2:KEAP1 pathway in response to oxidative stress and a chemically diverse group of compounds now known as "phase II inducers" (Rangsamy et al, 2004; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2000). NFE2L2 binds to the anti-oxidant response element (ARE) as a heterodimer with small MAF proteins like MAFK and upregulates NQO1 expression (Itoh et al, 1997; McMahon et al, 2001; Rangasamy et al, 2004; Malhotra et al, 2010). Binding and transcriptional activation by NFE2L2 at the NQO1 promoter is enhanced by CREBBP or EP300-mediated acetylation of NFE2L2 at 18 sites in the N-terminal Neh1 domain (Sun et al, 2009).
Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K
Ishii, T, Hatayama, I, Nabeshima, Y, Yamamoto, M, Takahashi, S, Satoh, K, Oyake, T, Hayashi, N, Igarashi, K, Itoh, K, Chiba, T, Katoh, Y
Shyr, C, Srivastava, S, Wakabayashi, N, Wasserman, WW, Singh, A, Malhotra, D, Biswal, S, Happel, C, Portales-Casamar, E, Kensler, TW, Arenillas, D
Yamamoto, M, Baird, L
Yamamoto, M, Srisuma, SS, Cho, CY, Zhen, L, Biswal, S, Thimmulappa, RK, Rangasamy, T, Petrache, I, Kensler, TW, Tuder, RM
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