Reactome | AcK-NFE2L2- dependent NQO1 gene expression

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AcK-NFE2L2- dependent NQO1 gene expression Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9759187] Rothfels, Karen, 2021-11-29
dbId	9759186
displayName	AcK-NFE2L2- dependent NQO1 gene expression
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily - Homo sapiens [Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9759080] NQO1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9759020] Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release [LiteratureReference:9759040] The diverse functionality of NQO1 and its roles in redox control [LiteratureReference:9758970] An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements [LiteratureReference:9759034] The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9944228] The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
maxDepth	1
modified	[InstanceEdit:9974211] Rothfels, Karen, 2025-11-20
name	AcK-NFE2L2- dependent NQO1 gene expression
output	[Complex:R-HSA-9759111] NQO1:FAD dimer [cytosol]
precedingEvent	[Reaction:R-HSA-9759141] AcK-NFE2L2, CHD6 and MAFK bind NQO1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9759185] Positive gene expression regulation by 'NQO1 gene:p-AcK-NFE2L2:CHD6:MAFK [nucleoplasm]'
regulationReference	[RegulationReference:9759183] Positive gene expression regulation by 'NQO1 gene:p-AcK-NFE2L2:CHD6:MAFK [nucleoplasm]' An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9759186
summation	[Summation:9759184] NQO1 (NAD(P)H:Quinone acceptor oxidoreductase type1) catalyz...
updateTrackers	[UpdateTracker:9953727] Update Tracker - [BlackBoxEvent:9759186] AcK-NFE2L2- dependent NQO1 gene expression - v93:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9953727] Update Tracker - [BlackBoxEvent:9759186] AcK-NFE2L2- dependent NQO1 gene expression - v93:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-9943962] CHD6, CHD7, CHD8, CHD9 subfamily [Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes