The NQO1 gene encodes an NAD(P)H dehydrogenase quinone 1 enz...

created [InstanceEdit:9759144] Rothfels, Karen, 2021-11-29
dbId 9759140
displayName The NQO1 gene encodes an NAD(P)H dehydrogenase quinone 1 enz...
modified [InstanceEdit:9944273] Rothfels, Karen, 2025-04-03
schemaClass Summation
text The NQO1 gene encodes an NAD(P)H dehydrogenase quinone 1 enzyme. NQO1 is one of a number of drug metabolism genes upregulated by the NFE2L2:KEAP1 pathway in response to oxidative stress and a chemically diverse group of compounds now known as "phase II inducers" (Rangsamy et al, 2004; Malhotra et al, 2010; reviewed in Baird and Yamamoto, 2000). NFE2L2 binds to the anti-oxidant response element (ARE) as a heterodimer with small MAF proteins like MAFK and upregulates NQO1 expression (Itoh et al, 1997; McMahon et al, 2001; Rangasamy et al, 2004; Malhotra et al, 2010). Binding and transcriptional activation by NFE2L2 at the NQO1 promoter is enhanced by CREBBP or EP300-mediated acetylation of NFE2L2 at 18 sites in the N-terminal Neh1 domain (Sun et al, 2009). NEF2L2 additionally interacts with the ATP-dependent chromatin remodeller CHD6 through the NFE2L2 C-terminal Neh3 domain (Nioi et al, 2005). Whether CHD-mediated ATP hydrolysis contributes to NQO1 gene expression has not been explicitly determined, but RNAi-knockdown of CHD6 expression abrogates basal and induced NQO1 expression in HeLa cells (Nioi et al, 2005).
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