Reactome | In cancer cells it has been shown that Snail (SNAI1) protein...

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created	[InstanceEdit:9759756] May, Bruce, 2021-12-11
dbId	9759755
displayName	In cancer cells it has been shown that Snail (SNAI1) protein...
literatureReference	[LiteratureReference:9756406] The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition [LiteratureReference:9766453] Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition [LiteratureReference:9756426] A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
modified	[InstanceEdit:9932013] Orlic-Milacic, Marija, 2024-12-15
schemaClass	Summation
text	In cancer cells it has been shown that Snail (SNAI1) protein binds the promoter of the E-Cadherin (CDH1) gene and represses expression of CDH1 (Batlle et al. 2000, Maturi et al. 2018, and inferred from mouse homologs). Repression of CDH1 by SNAI1 results in a reduction in CDH1 protein at the plasma membrane that causes loss of contact between epithelial cells during the epithelial to mesenchyme transition that is required for mesoderm formation (inferred from mouse embryos). SNAI1 efficient repression and binding to human and mouse CDH1 promoter require intact zinc finger motifs ZF1 and ZF2 (Villarejo et al. 2014). SMAD3:SMAD4 heterotrimer may be involved in the recruitment of SNAI1 to the CDH1 gene promoter (Vincent et al. 2009).

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