SARS-CoV-2 8 binds class I MHC

Stable Identifier
R-HSA-9755328
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen, lumenal side of endoplasmic reticulum membrane
ReviewStatus
5/5
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SARS-CoV-2 8 binds class I MHC
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During viral infection, T cells recognize the viral antigens presented by class I MHC. SARS-CoV-2 infection down-regulates class I MHC in both infected human angiotensin–converting enzyme 2 (hACE2)-expressing HEK293T cells and infected lung epithelial cells of hACE2 transgene mice (Zhang Y et al. 2021).
SARS-CoV-2 ORF8 (8), which has no orthologous protein in SARS-CoV-1 (Li T et al. 2020), was found to regulate the expression of class I MHC on the surface of the infected cells through an autophagy-dependent lysosomal degradation of class I MHC. Knockdown of viral 8 protein expression in SARS-CoV-2–infected cells restored class I MHC expression (Zhang Y et al. 2021). This interaction leads to impaired antigen presentation.

Literature References
PubMed ID Title Journal Year
34021074 The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Zhang, X, Song, Z, Liu, J, Yuan, Y, Li, Y, Liu, B, Wu, L, Li, R, Xiao, F, Chen, J, Zhang, H, Pan, T, He, X, Yu, F, Ma, X, Luo, B, Huang, W, Xia, B, Zhang, Y, Huang, F, Zhang, J, Chen, Y, Yan, S, Yang, T

Proc Natl Acad Sci U S A 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Shamovsky, V  (2021-10-27)
Reviewed
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2021-10-08)
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