During viral infection, T cells recognize the viral antigens...

created [InstanceEdit:9755396] Shamovsky, Veronica, 2021-10-08
dbId 9755411
displayName During viral infection, T cells recognize the viral antigens...
literatureReference
modified [InstanceEdit:9756123] Shamovsky, Veronica, 2021-10-12
schemaClass Summation
text During viral infection, T cells recognize the viral antigens presented by class I MHC. SARS-CoV-2 infection down-regulates class I MHC in both infected human angiotensin?converting enzyme 2 (hACE2)-expressing HEK293T cells and infected lung epithelial cells of hACE2 transgene mice (Zhang Y et al. 2021).
SARS-CoV-2 ORF8 (8), which has no orthologous protein in SARS-CoV-1 (Li T et al. 2020), was found to regulate the expression of class I MHC on the surface of the infected cells through an autophagy-dependent lysosomal degradation of class I MHC. Knockdown of viral 8 protein expression in SARS-CoV-2?infected cells restored class I MHC expression (Zhang Y et al. 2021). This interaction leads to impaired antigen presentation.
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