Reactome | IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

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IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:975168] Shamovsky, V, 2010-09-22
dbId	975185
displayName	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol] [Complex:R-HSA-975108] TRAF6:p-IRAK2 [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450125] IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
orthologousEvent	[Reaction:R-GGA-573297] TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation - Gallus gallus [Reaction:R-DDI-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Dictyostelium discoideum [Reaction:R-DME-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Drosophila melanogaster [Reaction:R-GGA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Gallus gallus [Reaction:R-DRE-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Danio rerio [Reaction:R-SSC-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Sus scrofa [Reaction:R-BTA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Bos taurus [Reaction:R-CFA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Canis familiaris [Reaction:R-RNO-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Rattus norvegicus [Reaction:R-MMU-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Mus musculus
output	[Complex:R-HSA-975137] p-IRAK2:oligo-TRAF6 [endosome membrane]
precedingEvent	[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:983288] Gillespie, ME, 2010-10-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975185
summation	[Summation:936956] The mechanism by which IRAK-2 induces TRAF6 E3 ligase activi...

Referrals

(hasEvent)	[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[BlackBoxEvent:R-HSA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane