IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

Stable Identifier
R-HSA-975185
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
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IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
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The mechanism by which IRAK-2 induces TRAF6 E3 ligase activity remains to be deciphered, but one possibility is that IRAK-2 may direct TRAF6 oligomerization.
Literature References
PubMed ID Title Journal Year
17878161 IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

Maloney, GM, Bowie, AG, Keating, SE, Moran, EM

J Biol Chem 2007
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Orthologous Events
TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation (Gallus gallus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Drosophila melanogaster)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Gallus gallus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Rattus norvegicus)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Sus scrofa)
Authored
Shamovsky, V  (2010-06-01)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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