Reactome | IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

Stable Identifier

R-HSA-975185

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane, cytosol

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
        
        IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
        
        IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)

General

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IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

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The mechanism by which IRAK-2 induces TRAF6 E3 ligase activity remains to be deciphered, but one possibility is that IRAK-2 may direct TRAF6 oligomerization.

Literature References

PubMed ID	Title	Journal	Year
17878161	IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination Keating, SE, Maloney, GM, Moran, EM, Bowie, AG	J Biol Chem	2007