IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

Stable Identifier
R-HSA-975185
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The mechanism by which IRAK-2 induces TRAF6 E3 ligase activity remains to be deciphered, but one possibility is that IRAK-2 may direct TRAF6 oligomerization.

Literature References
PubMed ID Title Journal Year
17878161 IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

Keating, SE, Maloney, GM, Moran, EM, Bowie, AG

J Biol Chem 2007
Participants
Participant Of
Orthologous Events
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Created