Reactome | IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

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IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11014326
displayName	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
eventOf	[Pathway:R-DDI-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DDI-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Homo sapiens
input	2 × [DefinedSet:R-DDI-166366-25] Homologues of TRAF6 [cytosol] [Complex:R-DDI-975108] TRAF6:p-IRAK2 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
output	[Complex:R-DDI-975137] p-IRAK2:oligo-TRAF6 [endosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-975185
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[BlackBoxEvent:R-DDI-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
(inferredTo)	[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

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