Reactome | Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane

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Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane Show undefined attributes

catalystActivity	[CatalystActivity:10025246] ubiquitin-protein transferase activity of p-IRAK2:oligo-TRAF6 [endosome membrane]
category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10025248
displayName	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
eventOf	[Pathway:R-MMU-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Polymerisation:R-MMU-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Mus musculus [Reaction:R-MMU-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane - Homo sapiens
input	[Complex:R-MMU-975137] p-IRAK2:oligo-TRAF6 [endosome membrane] 9 × [DefinedSet:R-MMU-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
output	[Complex:R-MMU-975164] p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]
precedingEvent	[Reaction:R-MMU-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-975147
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
(precedingEvent)	[Reaction:R-MMU-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation [Polymerisation:R-MMU-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
(inferredTo)	[BlackBoxEvent:R-HSA-975147] Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane

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