Reactome | FLT3 fusions:GRB2 bind GAB2

Schema > Reaction > Entries

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9703440
disease	[Disease:1500689] cancer
displayName	FLT3 fusions:GRB2 bind GAB2
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-9703438] FLT3 fusions phosphorylate GAB2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9606623] Active Flt3:Grb2 binds Gab2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-508239] GAB2 [cytosol] [Complex:R-HSA-9703378] p-Y FLT3 fusion dimers:GRB2 [cytosol]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 fusions:GRB2 bind GAB2
output	[Complex:R-HSA-9703352] p-Y FLT3 fusions:GRB2:GAB2 [cytosol]
precedingEvent	[Reaction:R-HSA-9703442] Phosphorylated FLT3 fusions bind GRB2 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9703440
summation	[Summation:9703414] The transforming ability of ETV6-FLT3 fusion proteins is red...

(precedingEvent)	[Reaction:R-HSA-9703438] FLT3 fusions phosphorylate GAB2
(hasEvent)	[Pathway:R-HSA-9703465] Signaling by FLT3 fusion proteins
(inferredTo)	[Reaction:R-MMU-9606623] Active Flt3:Grb2 binds Gab2

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