FLT3 fusions:GRB2 bind GAB2

Stable Identifier
R-HSA-9703440
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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FLT3 fusions:GRB2 bind GAB2
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The transforming ability of ETV6-FLT3 fusion proteins is reduced in a GAB2 null background, implicating signaling through this GRB2-interactor as critical for the oncogenic program driven by the fusions (Chonabayashi et al, 2013).

Literature References
PubMed ID Title Journal Year
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A

Leukemia 2013
Participants
Input
Output
Participates
as an event of
Inferred From
Active Flt3:Grb2 binds Gab2 (Mus musculus)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-10-06)
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