FLT3 fusions:GRB2 bind GAB2

Stable Identifier
R-HSA-9703440
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The transforming ability of ETV6-FLT3 fusion proteins is reduced in a GAB2 null background, implicating signaling through this GRB2-interactor as critical for the oncogenic program driven by the fusions (Chonabayashi et al, 2013).

Literature References
PubMed ID Title Journal Year
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Chonabayashi, K, Hishizawa, M, Kawamata, S, Nagai, Y, Ohno, T, Ishikawa, T, Uchiyama, T, Takaori-Kondo, A

Leukemia 2013
Participants
Participant Of
Inferred From
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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