Reactome | Active Flt3:Grb2 binds Gab2

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Active Flt3:Grb2 binds Gab2 Show undefined attributes

authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9606626] Varusai, Thawfeek, 2018-04-24
dbId	9606623
displayName	Active Flt3:Grb2 binds Gab2
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
followingEvent	[BlackBoxEvent:R-MMU-9606621] Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated - Mus musculus
input	[Complex:R-MMU-9604769] Active Flt3:Grb2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2685613] Gab2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active Flt3:Grb2 binds Gab2
orthologousEvent	[Reaction:R-HSA-9703440] FLT3 fusions:GRB2 bind GAB2 - Homo sapiens [Reaction:R-HSA-9606624] Active FLT3:GRB2 binds GAB2 - Homo sapiens
output	[Complex:R-MMU-9606625] Active Flt3:Grb2:Gab2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-9604768] Active Flt3 dimer binds Grb2 - Mus musculus
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9606623
summation	[Summation:9606629] Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a me...

Referrals

(precedingEvent)

[BlackBoxEvent:R-MMU-9606621] Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated

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