Acetylated, phosphorylated STAT3 and SIN3A bind to the IL2RG promoter downstream of ALK signaling to repress expression (Gambi et al, 2019). Repression of IL2RG is also promoted by the STAT3-dependent recruitment of DNMT1, resulting in promoter demethylation (Zhang et al, 2011).
Wasik, M, Liu, X, Zhang, Q, Kantekure, K, Wang, HY, Bhutani, G
Verma, A, Inghirami, G, Gambi, G, Wang, R, Elemento, O, Basso, V, Di Simone, E, Mondino, A, Ponzoni, M, Icardi, L, Ricci, L
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