AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter

Stable Identifier
R-HSA-9701557
Type
Reaction
Species
Homo sapiens
Compartment
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Acetylated, phosphorylated STAT3 and SIN3A bind to the IL2RG promoter downstream of ALK signaling to repress expression (Gambi et al, 2019). Repression of IL2RG is also promoted by the STAT3-dependent recruitment of DNMT1, resulting in promoter demethylation (Zhang et al, 2011).

Literature References
PubMed ID Title Journal Year
21715655 IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Wasik, M, Liu, X, Zhang, Q, Kantekure, K, Wang, HY, Bhutani, G

Proc. Natl. Acad. Sci. U.S.A. 2011
30692217 The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3

Verma, A, Inghirami, G, Gambi, G, Wang, R, Elemento, O, Basso, V, Di Simone, E, Mondino, A, Ponzoni, M, Icardi, L, Ricci, L

Cancer Res. 2019
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