IL2RG gene expression downstream of ALK signaling

Stable Identifier
R-HSA-9701556
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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IL2RG gene expression downstream of ALK signaling
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IL2RG gene expression is repressed by a complex of SIN3A and acetylated, phosphorylated STAT3 dimer downstream of ALK signaling (Gambi et al, 2019).

Literature References
PubMed ID Title Journal Year
30692217 The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3

Verma, A, Inghirami, G, Gambi, G, Wang, R, Elemento, O, Basso, V, Di Simone, E, Mondino, A, Ponzoni, M, Icardi, L, Ricci, L

Cancer Res. 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm] (Homo sapiens)
Active Unit
AcK685-p-Y705,S727 STAT3 dimer:SIN3A [nucleoplasm]
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-26)
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