Reactome | Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'

Schema > NegativeGeneExpressionRegulation > Entries

activeUnit	[EntityWithAccessionedSequence:R-HSA-212181] DNMT1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] - Homo sapiens
created	[InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
dbId	9850955
displayName	Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'
regulatedEntity	[BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling - Homo sapiens
regulator	[Complex:R-HSA-9850883] DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]
schemaClass	NegativeGeneExpressionRegulation

(regulation)	[RegulationReference:9850959] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
(regulatedBy)	[BlackBoxEvent:R-HSA-9701556] IL2RG gene expression downstream of ALK signaling

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