p-Y705, S727 STAT3 dimer binds CD274 gene

Stable Identifier
R-HSA-9701537
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Reaction
Species
Homo sapiens
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ALK induces expression of the plasma membrane immunosuppressive protein CD274, a ligand for the programmed cell death 1 receptor CD279. Interaction of CD274 with its CD279 receptor promotes normal T cell immune function and contributes to immune evasion in malignant cells (reviewed in Kythreotou et al, 2017). ALK-induced expression of CD274 depends on ALK kinase activity and promotes direct binding of STAT3 to its cognate site in the CD274 promoter as assessed by electrophoretic mobility shift assay (EMSA) and ChIP (Marzec et al, 2008).

Literature References
PubMed ID Title Journal Year
19088198 Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Liu, X, Wasik, MA, Zhang, Q, Wysocka, M, Goradia, A, Marzec, M, Ruggeri, BA, Paessler, M, Raghunath, PN, Wang, HY, Cheng, M

Proc. Natl. Acad. Sci. U.S.A. 2008
29097600 PD-L1

Kythreotou, A, Mauri, FA, Siddique, A, Pinato, DJ, Bower, M

J. Clin. Pathol. 2018
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