Reactome | p-Y705,S727-STAT3 dimer [nucleoplasm]

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p-Y705,S727-STAT3 dimer [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9850937] p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9850945] pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-9850942] pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9701537] p-Y705, S727 STAT3 dimer binds CD274 gene - Homo sapiens [Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated - Homo sapiens [Reaction:R-HSA-9851118] pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK - Homo sapiens [Reaction:R-HSA-9851106] p-Y705, S727 STAT3 dimer binds ICOS promoter - Homo sapiens [Reaction:R-HSA-9851122] p-Y705,S727 STAT3 dimer binds NOTCH gene - Homo sapiens [Reaction:R-HSA-9701534] p-Y705, S727 STAT3 dimer binds HIF1A gene - Homo sapiens [Reaction:R-HSA-9851071] STAT3, DNMT1 and HDAC1 bind PTPN6 gene - Homo sapiens
created	[InstanceEdit:9701456] Rothfels, Karen, 2020-09-26
dbId	9701457
displayName	p-Y705,S727-STAT3 dimer [nucleoplasm]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-9701429] p-Y705,S727-STAT3 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Mus musculus [Complex:R-RNO-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Canis familiaris [Complex:R-BTA-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Bos taurus [Complex:R-SSC-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Sus scrofa [Complex:R-XTR-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Gallus gallus [Complex:R-DME-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] - Dictyostelium discoideum
maxDepth	2
name	p-Y705,S727-STAT3 dimer
negativelyRegulates	[NegativeGeneExpressionRegulation:9850968] Negative gene expression regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]'
positivelyRegulates	[PositiveRegulation:9725350] Positive regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' [PositiveGeneExpressionRegulation:9850992] Positive gene expression regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' [PositiveRegulation:9718474] Positive regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants - Homo sapiens [Reaction:R-HSA-9701565] HDACs deacetylate p-STAT3 dimers - Homo sapiens [BlackBoxEvent:R-HSA-9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9701457

Referrals

(activeUnit)	[PositiveGeneExpressionRegulation:9850995] Positive gene expression regulation by 'pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9850983] Positive gene expression regulation by 'ICOS gene:p-STAT3 [nucleoplasm]' [NegativeGeneExpressionRegulation:9850968] Negative gene expression regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' [NegativeGeneExpressionRegulation:9850965] Negative gene expression regulation by 'DNMT1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9850990] Positive gene expression regulation by 'p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9701542] Positive gene expression regulation by 'p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9701540] Positive gene expression regulation by 'p-Y705, S727 STAT3 dimer:HIF1A gene [nucleoplasm]'
(regulator)	[PositiveRegulation:9725350] Positive regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' [PositiveGeneExpressionRegulation:9850992] Positive gene expression regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' [NegativeGeneExpressionRegulation:9850968] Negative gene expression regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' [PositiveRegulation:9718474] Positive regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]'
(hasComponent)	[Complex:R-HSA-9850945] pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm] [Complex:R-HSA-9850889] ICOS gene:p-STAT3 [nucleoplasm] [Complex:R-HSA-9850937] p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] [Complex:R-HSA-9850942] pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] [Complex:R-HSA-9701462] p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] [Complex:R-HSA-9701459] p-Y705, S727 STAT3 dimer:HIF1A gene [nucleoplasm]
(input)	[Reaction:R-HSA-9851118] pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK [Reaction:R-HSA-9851106] p-Y705, S727 STAT3 dimer binds ICOS promoter [Reaction:R-HSA-9851122] p-Y705,S727 STAT3 dimer binds NOTCH gene [Reaction:R-HSA-9851071] STAT3, DNMT1 and HDAC1 bind PTPN6 gene [Reaction:R-HSA-9701537] p-Y705, S727 STAT3 dimer binds CD274 gene [Reaction:R-HSA-9701534] p-Y705, S727 STAT3 dimer binds HIF1A gene [Reaction:R-HSA-9701531] p-Y705,S727 STAT3 is acetylated
(output)	[BlackBoxEvent:R-HSA-9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants [Reaction:R-HSA-9701565] HDACs deacetylate p-STAT3 dimers [BlackBoxEvent:R-HSA-9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus

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