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p-Y705,S727-STAT3 dimer [nucleoplasm]
Stable Identifier
R-HSA-9701457
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
DNMT1-dependent PTPN6 gene silencing (Homo sapiens)
pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
MECP2 binds the STAT5A gene (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
NPM1-ALK- and STAT3-dependent ICOS gene expression (Homo sapiens)
ICOS gene:p-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
NPM1-ALK- and STAT3-dependent TWIST gene expression (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
NPM1-ALK- and p-STAT3-dependent IRF4 gene expression (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
NPM1-ALK- and p-STAT3-dependent NOTCH gene expression (Homo sapiens)
p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
NPM1-ALK-dependent CEBPB gene expression (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
STAT3, DNMT1 and HDAC1 bind PTPN6 gene (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer binds ICOS promoter (Homo sapiens)
ICOS gene:p-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727 STAT3 dimer binds NOTCH gene (Homo sapiens)
p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)
p-Y705, S727 STAT3 dimer:HIF1A gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
CD274 gene expression downstream of ALK signaling (Homo sapiens)
p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
HDACs deacetylate p-STAT3 dimers (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)
p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)
p-Y705, S727 STAT3 dimer:HIF1A gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727 STAT3 is acetylated (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
Participants
components
x 2
p-Y705,S727-STAT3 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm] (Homo sapiens)
ICOS gene:p-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] (Homo sapiens)
pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer:HIF1A gene [nucleoplasm] (Homo sapiens)
as an input of
pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK (Homo sapiens)
p-Y705, S727 STAT3 dimer binds ICOS promoter (Homo sapiens)
p-Y705,S727 STAT3 dimer binds NOTCH gene (Homo sapiens)
STAT3, DNMT1 and HDAC1 bind PTPN6 gene (Homo sapiens)
p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)
p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)
p-Y705,S727 STAT3 is acetylated (Homo sapiens)
as an output of
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)
HDACs deacetylate p-STAT3 dimers (Homo sapiens)
p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)
This entity regulates
Negatively
STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing
(Homo sapiens)
Positively
NPM1-ALK-dependent CEBPB gene expression
(Homo sapiens)
NPM1-ALK- and STAT3-dependent TWIST gene expression
(Homo sapiens)
MECP2 binds the STAT5A gene
(Homo sapiens)
Inferred To
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Bos taurus)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Caenorhabditis elegans)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Canis familiaris)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Dictyostelium discoideum)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Drosophila melanogaster)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Gallus gallus)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Mus musculus)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Rattus norvegicus)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Sus scrofa)
p-Y705,S727-STAT3 dimer [nucleoplasm]
(Xenopus tropicalis)
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