Active ALK binds SRC

Stable Identifier
R-HSA-9700648
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Active ALK binds SRC
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Based on studies with the oncogenic fusion protein NPM-ALK, SRC (and potentially other SRC-family members) binds to activated ALK receptor. Binding depends on tyrosine residue 1358 and ALK kinase activity, identifying pY1358 as the SRC-binding site (Cussac et al, 2004). SRC signaling downstream of ALK contributes to cellular proliferation (Cussac et al, 2004; reviewed in Chiarle et al, 2008; Palmer et al, 2009).
Literature References
PubMed ID Title Journal Year
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
14563642 Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity

Roche, S, Duyster, J, Greenland, C, Morris, SW, Delsol, G, Bai, RY, Payrastre, B, Allouche, M, Cussac, D

Blood 2004
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
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Inferred From
Active ALK binds Src (Homo sapiens)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Turner, S  (2023-11-08)
Created
Rothfels, K  (2020-09-16)
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