Based on studies with the oncogenic fusion protein NPM-ALK, ...

created [InstanceEdit:9700663] Rothfels, Karen, 2020-09-16
dbId 9700644
displayName Based on studies with the oncogenic fusion protein NPM-ALK, ...
schemaClass Summation
text Based on studies with the oncogenic fusion protein NPM-ALK, SRC (and potentially other SRC-family members) binds to activated ALK receptor. Binding depends on tyrosine residue 1358 and ALK kinase activity, identifying pY1358 as the SRC-binding site (Cussac et al, 2004). SRC signaling downstream of ALK contributes to cellular proliferation (Cussac et al, 2004; reviewed in Chiarle et al, 2008; Palmer et al, 2009).
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